Inhibition or induction of p gp expression by coadministered drugs, food andor natural products may result in pharmacokinetic interactions that lead to unwanted side effects andor decreased effectiveness of treatment. Initially p gp was identified by its overexpression in multidrug resistant tumor cells. P gp has been reported to affect the pharmacokinetics of structurally and pharmacologically diverse substrates. Pglycoprotein 1 also known as multidrug resistance protein 1 mdr1 or atp binding cassette.
Pgp has been reported to affect the pharmacokinetics of structurally and pharmacologically diverse substrates. Abstract pglycoprotein pgp, a protein encoded by the multidrug resistance gene 1 mdr1, functions as a transporter that promotes cellular efflux of a. P glycoprotein p gp is a transporter protein associated with multidrug resistance to certain anticancer drugs mdr. Pgp is also expressed in a wide range of normal tissues including liver. Free le basi della farmacologia pdf download bernardshaw. From the bestselling author of why we get fat, a groundbreaking, eyeopening expose. Glicoproteinap, resistencia a multiplas drogas mdr e relacao. Veja gratis o arquivo farmacologia farmacocinetica e farmacodinamica. Pglycoprotein 1 permeability glycoprotein, abbreviated as pgp or pgp also known as multidrug resistance protein 1 mdr1 or atpbinding cassette subfamily b member 1 abcb1 or cluster of differentiation 243 cd243 is an important protein of the cell membrane that pumps many foreign substances out of cells. Review multidrug resistance mdr1 gene and pglycoprotein. Inhibition or induction of pgp expression by coadministered drugs, food andor natural products may result in pharmacokinetic interactions that lead to unwanted side effects andor decreased effectiveness of treatment.
Universita degli studi di siena dipartimento di farmacologia g. Pglycoprotein pgp is a transporter protein associated with multidrug resistance to certain anticancer drugs mdr. Results showed a polarized permeation in the basaltoapical direction, reduced by inhibitors of the transporter 0. Read online or download ebook le basi della farmacologia pdf free in pdf, epub, mobi, doc, and txt format for free. A glicoproteinap gpp foi descrita pela primeira vez em 1976 como uma. Parte estos y sus metabolitos pueden excretarse en heces 6. There is a wide difference of therapy response between species. Temario completo farmacologia eui sant pau 20112012. Glicoproteina p o atpasi trasportatrice di farmaci. P glycoprotein 1 permeability glycoprotein, abbreviated as p gp or pgp also known as multidrug resistance protein 1 mdr1 or atpbinding cassette subfamily b member 1 abcb1 or cluster of differentiation 243 cd243 is an important protein of the cell membrane that pumps many foreign substances out of cells. O papel da glicoproteina p nas interacoes farmacofarmaco. P gp is also expressed in a wide range of normal tissues including liver, intestines, bloodbrain barrier and kidneys. Initially pgp was identified by its overexpression in multidrug resistant tumor cells. Papel da glicoproteinap na farmacocinetica e nas interacoes.